Digging deeper, there are other cell-type specific features.
Psilocybin increases calcium activity in the apical dendrites of PT neurons, but not IT neurons.
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Psilocybin increases calcium activity in the apical dendrites of PT neurons, but not IT neurons.
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Comments
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It has long been debated whether serotonin 2A receptor is needed. We took a precise approach, using a conditional knockout mouse to show that deleting the receptor in frontal cortex abolishes psilocybin’s long-term behavioral effects.
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These are strong evidence supporting the role of serotonin 2A receptors in psychedelic drug action.
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The short- and long-term effects of psilocybin are mediated by different circuits, with the PT neurons in frontal cortex sitting at the core of the long-term response.
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Additional support from NIH/NIDA @onemindorg.bsky.social and the Source Research Foundation 🙏
A collaborative effort between my team at @cornellengineering.bsky.social, KAIST, and @aliciache.bsky.social at Yale Psychiatry 🤝
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https://doi.org/10.1038/d41586-025-00979-3
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