@samcwoodburn.bsky.social previously tested 2 mg/kg psilocybiin, among many other conditions, for fear extinction. pubs.acs.org/doi/full/10.... The results are very close... Ours in the top, the cross-lab average in the bottom - ThreadSky

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alexkwan.bsky.social • 33 days ago

@samcwoodburn.bsky.social previously tested 2 mg/kg psilocybiin, among many other conditions, for fear extinction.
https://pubs.acs.org/doi/full/10.1021/acschemneuro.4c00279

The results are very close... Ours in the top, the cross-lab average in the bottom

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alexkwan.bsky.social•33 days ago

Though the authors cautioned about variability across labs. Seems to me that two labs did not see an effect, and two labs saw a mild effect. The final lab saw a large effect, which drove the pooled results.

alexkwan.bsky.social•33 days ago

Another note -

For learned helplessness, initially we tested the same animal before and after drug, for a within-subject design in the 2021 Neuron paper. There may be confound because we saw hints that mice learn from the test for the re-test..

In the 2025 paper, we only did one test after drug.

alexkwan.bsky.social•33 days ago

I wonder if how this assay choice affected the results from the preprint when they test the persisting effect via FST and TST.

alexkwan.bsky.social•33 days ago

Overall, this effort reminded me of this excellent @simonsfoundation.org SFARI led study to characterize ASD mouse models comprehensively.

They could not replicate some earlier findings, and the effect size tends to be milder than what individual labs report

https://pubmed.ncbi.nlm.nih.gov/28753255/

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