2x Preprint drop!!! Mitochondrial pearling has arrived! “The Biophysical Mechanism of Mitochondrial Pearling”. “Pearling Drives Mitochondrial DNA Nucleoid Distribution” 1/10 www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1... - ThreadSky

gavsturm.bsky.social • 65 days ago

2x Preprint drop!!! Mitochondrial pearling has arrived!
“The Biophysical Mechanism of Mitochondrial Pearling”.
“Pearling Drives Mitochondrial DNA Nucleoid Distribution” 1/10
https://www.biorxiv.org/content/10.1101/2024.12.21.629509v1
https://www.biorxiv.org/content/10.1101/2024.12.21.629917v1

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pm-lab.bsky.social•65 days ago

Congratulations. Wonderful study!

johannes-pilic.bsky.social•50 days ago

This is fascinating, congratulations!

gavsturm.bsky.social•65 days ago

Warning. Once you see it, you can’t unsee it. Fast spontaneous movements in which mitochondrial tubules transiently convert to thinly connected spheres (i.e. like a pearled necklace). So what is this strange event? 2/10

gavsturm.bsky.social•65 days ago

You may be thinking of fission machinery. DRP1? a GTPase-like protein? but alas not quite! osmotic shock, ionophores, chemical fixation, membrane permeabilization, micro-needle force, laser-stimulation all induce mitochondrial pearling! we needed a more fundamental explanation…physics! 3/10

gavsturm.bsky.social•65 days ago

It's all physics. Using creative microscopic perturbations we establish that the 19th century Rayleigh-Plateau Pearling instability is the only model capable of explaining this event. This lead us to 3 physical forces; tension, pressure, and elasticity regulating pearling. Video by @Caleb_J_Rux 4/10

gavsturm.bsky.social•65 days ago

What is the functional utility of pearling? The brilliant investigation of @jclandoni.bsky.social .social and @sulianamanley.bsky.social establish mitochondrial pearling as the first and only known mechanism for mitochondrial DNA disaggregation and regular distribution. 5/10
https://bsky.app/profile/jclandoni.bsky.social/post/3ldyeicx6xk2v

gavsturm.bsky.social•65 days ago

Other possible functions of pearling are emerging. We captured spontaneous pearling in diverse cell types including in important physiological events such neuronal action potentials, in T cell immune synapses, and in replicative senescence. There are so many exciting possibilities ahead! 6/10

gavsturm.bsky.social•65 days ago

How did we image this rapid event sometimes occurring within a second of time? thanks to @kayleyhake.bsky.social @andrewgyork.bsky.social & @amsikking.bsky.social @Calico we got to observe this biology with the best microscope in the word (imo), SNOUTY 7/10

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