What is the functional utility of pearling? The brilliant investigation of @jclandoni.bsky.social .social and @sulianamanley.bsky.social establish mitochondrial pearling as the first and only known mechanism for mitochondrial DNA disaggregation and regular distribution. 5/10 bsky.app/profile/jcla... - ThreadSky

gavsturm.bsky.social • 66 days ago

What is the functional utility of pearling? The brilliant investigation of @jclandoni.bsky.social .social and @sulianamanley.bsky.social establish mitochondrial pearling as the first and only known mechanism for mitochondrial DNA disaggregation and regular distribution. 5/10
https://bsky.app/profile/jclandoni.bsky.social/post/3ldyeicx6xk2v

Reposted from Juan C. Landoni 🔬

Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

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gavsturm.bsky.social•66 days ago

Other possible functions of pearling are emerging. We captured spontaneous pearling in diverse cell types including in important physiological events such neuronal action potentials, in T cell immune synapses, and in replicative senescence. There are so many exciting possibilities ahead! 6/10

gavsturm.bsky.social•66 days ago

How did we image this rapid event sometimes occurring within a second of time? thanks to @kayleyhake.bsky.social @andrewgyork.bsky.social & @amsikking.bsky.social @Calico we got to observe this biology with the best microscope in the word (imo), SNOUTY 7/10

gavsturm.bsky.social•66 days ago

The imaging data here includes over a 1000 videos of 4D light-sheet images. Crunching through this much image analysis was only possible thanks to @austin-lefebvre.bsky.social brand new automated organelle tracking platform, Nellie, 8/10
https://github.com/aelefebv/nellie

gavsturm.bsky.social•66 days ago

Studying this specific event goes all the way back to 1915, and has been given many names since. Take a close look at Margaret Lewis's hand-drawn mitochondria. However, a comprehensive model has been missing... 9/10

pm-lab.bsky.social•65 days ago

Can you please share the reference for this drawing?

gavsturm.bsky.social•65 days ago

absolutely! well ahead of its time and not well known enough: https://onlinelibrary.wiley.com/doi/10.1002/aja.1000170304

gavsturm.bsky.social•66 days ago

Thanks to my PhD advisor @wallaceucsf.bsky.social and all of our amazing collaborators, our biophysical model lays the groundwork for understanding pearling as a essential mitochondrial dynamic; integrating ionic flux, inter-organelle interactions, molecular motors, and bioenergetics. 10/10

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