Monoclonal antibodies in #Alzheimers clear amyloid plaques and increase Aβ42. High Aβ42 levels improve cognition. Removing amyloid comes with risks: brain edema ('ARIA') and faster brain atrophy. The trade-off is not worth it.

A nice summary @psypost.bsky.social https://www.psypost.org/neuroscientists-just-turned-a-major-alzheimers-theory-on-its-head