Thrilled to share that our manuscript on strain-level gut microbiome variation across diverse populations and human phenotypes is out today in @cellpress.bsky.social
Curious about how strain diversity relates to human traits? Follow this thread! 🌍 (1/n)
https://www.sciencedirect.com/science/article/pii/S0092867425004167
Curious about how strain diversity relates to human traits? Follow this thread! 🌍 (1/n)
https://www.sciencedirect.com/science/article/pii/S0092867425004167
Comments
We analyzed >32,000 public metagenomes, profiled species marker genes at single-nucleotide resolution with StrainPhlAn, and built ~600 species phylogenies. (2/n)
Species with stronger stratification were less often shared across individuals, suggesting limited dispersal drives the observed geographic patterns. (3/n)
Association analysis revealed multiple phenotype–species links, including strong, reproducible associations between R. gnavus and age, and C. aerofaciens and melanoma. (4/n)
Interestingly, individuals with prostate cancer also clustered here! (6/n)
We provide a list of strain-phenotype associations and large phylogenies, hoping they’ll spark further interest in the community. (7/n)
Ruminoccocus gravus is a common member of the gut microbiome. When we looked into the genetics of this bacterium, we saw that older individuals harbored bacteria of similar genetics makeup, while this was not observed in younger people. (1/2)