Phenome-wide association studies (PheWAS) are a powerful tool for uncovering drug repurposing opportunities and unexpected side effects of novel targets📊 🧬
The best open-access resources for PheWAS analyses👇
The best open-access resources for PheWAS analyses👇
Comments
👉Detailed phenotyping from multiple sources (diagnostic codes, self-report, operations/rpocedures, prescriptions)
👉~20,000 non-Europeans
📊Access to individual-level data upon application or summary GWAS files available here: https://pan.ukbb.broadinstitute.org
👉Diagnoses derived from electronic health records of US veterans participating in the study
👉29% non-European
📊GWAS summary stats are free to download here: https://ftp.ncbi.nlm.nih.gov/dbgap/studies/phs002453/analyses/GIA/
👉endpoints extracted from nationawide registries (ICD diagnoses, procedures, prescriptions)
👉almost exclusively individuals of Finnish ancestry
📊GWAS summ stats available here: https://finngen.fi/en/access_results
👉diagnoses were derived from medical records and were afterwards harmonized
👉exclusively individuals of Japanese ancestry
📊GWAS summary stats free to download from this link: http://jenger.riken.jp/en/result
https://mvp-ukbb.finngen.fi/