I always come back to @romainbrette.bsky.social's point about the difference between details vs realism in models
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004114
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004114
Comments
The wooden model is useless. But the paper plane needs an upgrade to make a prediction.
An ML model needs a mechanistic upgrade (or data, it's another topic) to predict perturbations
I think "perturbations testing" emerges as a good way to validate mechanisms inside data-constrained models.