New hope for viral coinfection-based therapeutic approach against Herpesviruses!
Gene Drive(GD), a self propagating gene-editing technique via Cas9 mediated homologous recombination inserts the GD with red fluorescent (mCherry) into HSV-1 genome. Specific and non-specific (GD-ns) gRNA were tested.
Gene Drive(GD), a self propagating gene-editing technique via Cas9 mediated homologous recombination inserts the GD with red fluorescent (mCherry) into HSV-1 genome. Specific and non-specific (GD-ns) gRNA were tested.
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Infection with WT+GD was spread widely in neuronal tissues
This highlights the potential to target latent viral genome for therapy and finding a cure