Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. It reveals obesity-induced changes in facial nerves & body-wide inflammation 👉🧵https://biorxiv.org/content/10.1101/2024.08.18.608300v1.full.pdf - ThreadSky

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erturklab.bsky.social • 83 days ago

Imagine seeing a disease's impact on every cell in the body. Now, you can! We introduce MouseMapper, an AI tool to reveal system-wide disease perturbations. It reveals obesity-induced changes in facial nerves & body-wide inflammation 👉🧵https://biorxiv.org/content/10.1101/2024.08.18.608300v1.full.pdf

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spaceape777.bsky.social•83 days ago

I can't open the link.

markuselsner.bsky.social•83 days ago

https://www.biorxiv.org/content/10.1101/2024.08.18.608300v1

erturklab.bsky.social•83 days ago

Our most recent bioRxiv work is now also on Blueskpy!!!

The work is lead by @dorie00.bsky.social Doris Kaltenecker, Izabela Horvath, Rami Al-Maskari, Zeynep Ilgin Kolabas,Ying Chen @rami

erturklab.bsky.social•83 days ago

MouseMapper transforms how we study systemic diseases like obesity. Here’s a deep dive into what it does and why it matters.

erturklab.bsky.social•83 days ago

Diseases like obesity affect multiple organ systems, highlighting the interconnected nature of our body's physiology. To truly understand these systemic effects, we need holistic tools for studying cellular changes on a whole-body scale.

erturklab.bsky.social•83 days ago

Thanks to tissue clearing and light-sheet imaging, we can visualize entire mouse bodies at single-cell resolution. But quantifying structures like nerves on a whole-body scale has been a major challenge – until now.

erturklab.bsky.social•83 days ago

To see how obesity affects the body, we used vDISCO clearing and imaging to visualize the peripheral nervous system in both lean and obese mice.

erturklab.bsky.social•83 days ago

Additionally, we visualized infiltrating CD68-EGFP immune cells linked to chronic inflammation in obesity on the whole-body scale.

scottakenhead.bsky.social•50 days ago

Gobsmacked! Thank you.
Next-gen medicine: similar scans of my own body, with attendant diagnoses, warnings, and advice.

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