🚨 Our latest research in @naturecomms.bsky.social shows a promising strategy for less resistance-prone #antibiotics. For details, see the thread below and read the paper “Exploring the principles behind antibiotics with limited resistance” here: #MEvoSky https://www.nature.com/articles/s41467-025-56934-3
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By combining membrane disruption with another key cellular pathway, we can dramatically limit bacterial #resistance. This “double whammy” makes it much harder for bacteria to fight back. #RationalDesign #Antibiotics
We tested three promising #DrugCandidates – POL7306, Tridecaptin M152-P3, and SCH79797 – against tough #ESKAPE pathogens like E. coli, K. pneumoniae, A. baumannii, and P. aeruginosa. The results? #ResistanceEvolution was significantly limited.
Dual-target topoisomerase antibiotics, despite having two intracellular targets, were more prone to resistance. This highlights that which targets matter just as much as how many. #DrugDevelopment
These insights provide a blueprint for developing next-gen antibiotics ( #FutureAntibiotics) designed to stay one step ahead of bacterial defenses. It’s a promising direction in the fight against #AntibioticResistance #AMR.
This work was spearheaded by @m-elvin.bsky.social and @marczikkely.bsky.social at HUN-REN Biological Research Centre, Szeged