Recent protein backbone design methods don't appear to uniformly improve upon pre-DL methods. This was evidenced by RFDiffusion's failure at motif scaffolding of two proteins that were designed by earlier methods arxiv.org/abs/2502.12479 - ThreadSky

ddelalamo.bsky.social • 7 days ago

Recent protein backbone design methods don't appear to uniformly improve upon pre-DL methods. This was evidenced by RFDiffusion's failure at motif scaffolding of two proteins that were designed by earlier methods https://arxiv.org/abs/2502.12479

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