🚨New review🚨 Evolution and ecology of anti-defence systems in phages and plasmids Link: www.cell.com/current-biol... - ThreadSky

dcswarts.bsky.social • 47 days ago

🚨New review🚨

Evolution and ecology of anti-defence systems in phages and plasmids

Link: https://www.cell.com/current-biology/fulltext/S0960-9822(24)01574-4?rss=yes

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dcswarts.bsky.social•47 days ago

Together with Stineke van Houte and Edze Westra, @tniault.bsky.social describes how anti-defence systems evolved, and what ecological drivers and consequences of defense system/anti-defense system interactions are.

dcswarts.bsky.social•47 days ago

Recently very good reviews provided elaborate overviews of different anti-defence mechansms were published, so that is not the focus of this review.

You can find a selection here:
https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00683-6
https://www.nature.com/articles/s41576-023-00676-9
https://www.cell.com/trends/microbiology/pdf/S0966-842X(24)00136-7.pdf

dcswarts.bsky.social•47 days ago

We review the origins of anti-defence mechanisms, e.g. through co-option of prokaryotic proteins by plasmids and phages, defence component co-option and mutation, and de novo evolution.

We also discuss the selective pressure that acts on anti-defence system maintenance.

dcswarts.bsky.social•47 days ago

We review how regulation of anti-defense systems expression can be of importance, and how defence systems and their anti-defence systems have co-evolved in the arms race between bacterial hosts and their mobile genetic elements.

dcswarts.bsky.social•47 days ago

Finally, we discuss ecological drivers and consequences of interactions between defence and anti-defence systems.

dcswarts.bsky.social•47 days ago

We propose that beyond unraveling new anti-defence mechanisms, efforts should also aim to clarify the evolutionary and ecological drivers of anti-defence systems, which currently remain poorly explored.

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