H5N1 We are currently at stage 3 in the virus's progression, transitioning from the avian phase to the mammalian phase, and now entering the stage of potential human spillover. - ThreadSky

ciagw.bsky.social•106 days ago

Ugh please no.

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blackgoo.bsky.social•107 days ago

Not scary at all. 😳

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mamadonnae.bsky.social•106 days ago

just in time for Scump's next pandemic presidency

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danivass.bsky.social•106 days ago

📌

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aparachick.bsky.social•106 days ago

Did you see the post by @scottehensley.bsky.social ?

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sakuraskies.bsky.social•106 days ago

This happening with the Fanta Fascist in office keeps me up at night.

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angelgonzalez.bsky.social•105 days ago

📌

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ejustin46.bsky.social•107 days ago

2) DECODING NON-HUMAN MAMMALIAN ADAPTIVE SIGNATURES of 2.3.4.4b H5N1 to ASSESS its HUMAN ADAPTIVE POTENTIAL
https://www.biorxiv.org/content/10.1101/2024.08.26.609722v1

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ejustin46.bsky.social•107 days ago

3) The study analyzed how the highly pathogenic H5N1 flu virus evolved as it infected different non-human mammals. The virus quickly adapted to the new hosts, with changes seen mostly in the NS1 protein and the polymerase complex.

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ejustin46.bsky.social•107 days ago

4) While the key HA protein had fewer adaptations, some mutations altered its glycosylation, which affects how the virus binds to cells.
Compared to past H5N1 strains, the 2.3.4.4b clade acquired a unique mutation in PB2 that helps the virus adapt to humans.

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ejustin46.bsky.social•107 days ago

5) Viruses from certain mammals, like foxes, dolphins, bears, and cattle, gained more human-adaptive mutations in the polymerase, suggesting higher potential to infect and spread among people.

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ejustin46.bsky.social•107 days ago

6) However, some adaptations in other proteins could act as barriers to human transmission. Overall, the study highlights how rapidly H5N1 is evolving in non-human hosts and ...