Proud of this work spearheaded by the phenomenal @jlfan.bsky.social and @mingxz.bsky.social in collaboration w/ Ben Izar! The past 3 years we've worked hard to unravel how #CNVs shape #tumor phenotypic plasticity seen in #singlecell #RNAseq data ➡️ #Echidna 🦔 - ThreadSky

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elhamazizi.bsky.social • 72 days ago

Proud of this work spearheaded by the phenomenal @jlfan.bsky.social and @mingxz.bsky.social in collaboration w/ Ben Izar! The past 3 years we've worked hard to unravel how #CNVs shape #tumor phenotypic plasticity seen in #singlecell #RNAseq data ➡️ #Echidna 🦔

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elhamazizi.bsky.social•72 days ago

#Phenotypic plasticity has emerged as a key concept in #tumorigenesis, tumor progression and #resistance to targeted treatments and #immunotherapies in cancer and beyond.

elhamazizi.bsky.social•72 days ago

We aimed to find out if transcriptional changes are merely a consequence of #intrinsic gene dosage differences
between #cancer #clones, and wanted to separate this effect from plasticity induced through #extrinsic interactions with other cells of the #TME or non-genomically encoded events!

elhamazizi.bsky.social•72 days ago

#Echidna 🦔 addresses this question with a #Bayesian hierarchical model that links copy number alterations to phenotypic plasticity within one sample or #longitudinal multi-timepoint samples! Check out the details: https://bsky.app/profile/jlfan.bsky.social/post/3ldlhpy73422d
@columbiauniversity.bsky.social

elhamazizi.bsky.social•72 days ago

Stay tuned for #Echidna's impact in a cohort of immunotherapy-treated melanoma patients!
#machinelearning #cancerimmunology

kieranrcampbell.bsky.social•72 days ago

Lovely work!

elhamazizi.bsky.social•72 days ago

Thank you!

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