I’m excited to share our new paper published in Nature Communications! In our work, we discovered TANB77, a bacterial clade previously obscured by a polyphyletic grouping in conventional taxonomy, as a reliable biomarker across diverse immunotherapy recipient groups. www.nature.com/articles/s41... - ThreadSky

About ThreadSky

I’m excited to share our new paper published in Nature Communications!
In our work, we discovered TANB77, a bacterial clade previously obscured by a polyphyletic grouping in conventional taxonomy, as a reliable biomarker across diverse immunotherapy recipient groups.
https://www.nature.com/articles/s41467-024-55388-3

Comments

chanyeong-kim.bsky.social•60 days ago

Despite its prevalence as a human commensal, TANB77 remains an uncultured and understudied clade, unrecognized due to the limitations of conventional taxonomy. In NCBI taxonomy, TANB77 is confounded with unrelated taxa. We therefore refined our taxonomic classification by adopting GTDB taxonomy.

chanyeong-kim.bsky.social•60 days ago

We validated our findings through mouse experiments, showing that mice with higher gut TANB77 abundance, either naturally or through FMT, exhibited an improved response to anti-PD-1 therapy.

chanyeong-kim.bsky.social•60 days ago

We discovered a pilus gene complex exclusive to TANB77. We showed that the synthesized pilin stimulates DCs through the TLR4 pathway. Administering pilin as an adjuvant to therapy in mice enhances ICB efficacy, with single-cell analysis revealing changes in the tumor immune microenvironment.

chanyeong-kim.bsky.social•60 days ago

Our study emphasizes the importance of using standardized taxonomy to uncover features hidden within microbial dark matter. Our findings also offer significant translational potential for developing microbial biomarkers and therapeutic adjuvants for ICB treatment.
Thanks to all involved! :)

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