PNUTS was previously known for its role in transcription termination. Surprisingly, however, we found that without PNUTS, PolII is stuck at the 5'-end and does not enter into productive elongation. This leads to the dramatic reduction in the transcription of virtually every PolII-transcribed gene.
Have a look at our paper to find out more about how PNUTS might be doing this. This was a manic ride but a truly enjoyable team effort! Shout out to my co-author @jesskelley.bsky.social and to everyone else from the @robklose.bsky.social
Also, isn't it amazing when great findings are done independently by two groups from completely different parts of the world and those are published together? Fei Chen's group has also just published a complementary story on the role of PNUTS in pause release https://www.cell.com/molecular-cell/abstract/S1097-2765(24)00885-2
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