SK talks about two cardiovascular fraud cases, as described here: www.science.org/doi/10.1126/... www.reuters.com/investigates... These studies can have a big impact on a field. #AUC2025 - ThreadSky

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elisabethbik.bsky.social • 45 days ago

SK talks about two cardiovascular fraud cases, as described here:
https://www.science.org/doi/10.1126/science.6828878
https://www.reuters.com/investigates/special-report/health-hearts-stem-cells/
These studies can have a big impact on a field.
#AUC2025

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elisabethbik.bsky.social•45 days ago

SK: many trials have tried to reproduce the (later found to be fraudulent) cardiac stem cells findings and failed.
In another example, a fraudulent trial led to change in guidelines, but was never reproduced. Papers never retracted.
https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(12)00386-5
#AUC2025

elisabethbik.bsky.social•45 days ago

SK - @kaulcsmc.bsky.social : Many failures in studies on Vioxx or meta-analysis on Rosiglitazone, aspirin.
Quote by Bangalore&Messerli : "A meta-analysis is like a sausage; only God and the butcher know what goes in it, and neither would ever eat any."
https://pmc.ncbi.nlm.nih.gov/articles/PMC8673369/

#AUC2025

elisabethbik.bsky.social•45 days ago

SK: It takes the combined responsibility of all stakeholders to flag and correct/remove fraudulent papers.
Chopra and Eagle quote: "The consequences of research fraud are legion [...] The price of academic misconduct is simply too great to pay."
https://www.amjmed.com/article/S0002-9343(12)00386-5/fulltext

#AUC2025

ruibenedito.bsky.social•45 days ago

Unfortunately also many follow up papers claimed to reproduce part of the fake findings. There is always a large wave of followers (that takes a long time to hit the coast and flatten out).

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