Doctored by Charles Piller review – the scandal that derailed Alzheimer’s research A dogged account of how the quest for a treatment may have been set back years by fraudulent evidence www.theguardian.com/books/2025/f... - ThreadSky

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elisabethbik.bsky.social • 1 day ago

Doctored by Charles Piller review – the scandal that derailed Alzheimer’s research
A dogged account of how the quest for a treatment may have been set back years by fraudulent evidence

https://www.theguardian.com/books/2025/feb/20/doctored-by-charles-piller-review-the-scandal-that-derailed-alzheimers-research

Comments

tai-md.com•1 day ago

Can someone from #NeuroSky explain what is the most up to date on Alzheimer’s. Is Amyloid still part of it or it’s totally non-sense/irrelevant?

tajfisher.bsky.social•1 day ago

Hey, I'm working on this for my PhD right now. So, yes amyloid is definitely still important. The main distinction is amyloid plaques, non-soluble, vs amyloid oligomers, smaller soluble assemblies of amyloid-Beta protein. Best evidence suggests ABeta42 oligomers are toxic, especially at synapses. /

tajfisher.bsky.social•1 day ago

Plaques seem to be the aftermath of the disease. One way to think about it is the oligomers are cutting the brakes on an out of control train going downhill, while the plaques are the accident scene after the crash. We don't know why too many oligomers start to form and can't be controlled, but /

tajfisher.bsky.social•1 day ago

but once they have formed they wreak havoc. Clearing plaques doesn't prevent Alzheimer's anymore than cleaning up the accident scene stops the train crash. My take is that several insults over the course of a life i.e. cholesterol, TBI, hypertension, chronic inflammation, infection, etc. /

tajfisher.bsky.social•1 day ago

in old age cause some dysregulation of amyloid production and clearance allowing it to accumulate and start causing damage.

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