#PathSky 67F, s/p lumpectomy and RT 5 yrs ago for DCIS, now with a mass IN the breast. The outside was worried about post RT angiosarcoma, in part because of the CD31 and C-MYC. This is just fat necrosis with CD31-pos macrophages. 1- post RTAS occurs in the SKIN, not breast. 2- macs express CD31.
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(Oh- CD68 is also highly nonspecific. It’s a marker of lysosomes. I use CD163.) and with that- HNY!