What did we find? Applied to tumor samples: 1️⃣ Clonal structure reconstructed with higher accuracy vs InferCNV/Numbat. 2️⃣ Temporal dynamics captured: tracks clonal evolution pre/post therapy. 3️⃣ Drivers of resistance identified using GDX in genomic hotspots. 4/
Comments
S100 family and MHC-II genes. #Echidna also disentangles intrinsic (CNA-driven) vs extrinsic expression immune signaling!
Read more here: https://www.biorxiv.org/content/10.1101/2024.12.15.628568v1
Let’s unravel tumor evolution, one clone at a time! 7/7