A nucleosome switch primes #hepatitis B virus infection.

Chromatinization of cccDNA promotes transcription of the critical HBV X gene.
The nucleosome-destabilizing drug CBL137 disrupts chromatin organization of the X gene & inhibits #HBV infection.

https://www.cell.com/cell/abstract/S0092-8674(25)00102-3?dgcid=raven_jbs_aip_email #MicroSky #IDSky