Bacterial immunotherapy leveraging IL-10R hysteresis for phagocytosis evasion & tumor immunity revitalization.

IL-10 induces IL-10R expression, forming a positive feedback loop & hysteresis.
Bacteria induce TAMs to secrete IL-10, activating CD8+ TRM cells

https://www.cell.com/cell/abstract/S0092-8674(25)00158-8?dgcid=raven_jbs_aip_email #ImmunoSky