The worst problem we have? it's not fraud, or mistreatment, or whatever. It's that people and organisations that run science have no understanding of human motivation. Which leads inevitably to fraud, mistreatment of others, and whatever.
https://www.science.org/content/article/nih-launches-initiative-double-check-biomedical-studies
https://www.science.org/content/article/nih-launches-initiative-double-check-biomedical-studies
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