Vagal signals are classically seen as inhibitory but there is lots of evidence suggesting they are way more adaptive than that. @nbkroemer.bsky.social and I packed them into an easily digestible TiCS review for you to feast on 🔥 50 day free access, and a little appetizer 👇 🧠🟦 tinyurl.com/bdh279jv - ThreadSky

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glassybrain.bsky.social • 453 days ago

Vagal signals are classically seen as inhibitory but there is lots of evidence suggesting they are way more adaptive than that. @nbkroemer.bsky.social and I packed them into an easily digestible TiCS review for you to feast on 🔥 50 day free access, and a little appetizer 👇 🧠🟦
https://tinyurl.com/bdh279jv

Comments

glassybrain.bsky.social•453 days ago

An extensive network of vagal sensory neurons transmit interoceptive information from peripheral organs to the brainstem. And the target brain networks are just as extensive, orchestrating sensory, metabolic, affective, cognitive, and motor processing 🤯

glassybrain.bsky.social•453 days ago

We see evidence that boosting bottom-up vagal signaling, using for example electrical stimulation of the vagus nerve, changes high-level functions (motivation, memory, learning) in a state-dependent way.

glassybrain.bsky.social•453 days ago

So, gating vagally transmitted bodily demands in the brainstem could amplify reward responses for actions that address these demands best 🧠⚖️

glassybrain.bsky.social•453 days ago

This mode of function has implications for vagus nerve stimulation as a clinical tool because therapeutic effects will be state-dependent as well (for example hunger vs satiety). This could offer an explanation for the well-known heterogeneity in clinical outcomes.

glassybrain.bsky.social•453 days ago

Check out the full review for a more in-depth discussion on how to put this theory to the test and open questions for all of us to address in upcoming studies! 📈

glassybrain.bsky.social•453 days ago

I thoroughly enjoyed thinking about the meaning of vagal signals with @nbkroemer.bsky.social and the resulting review is not only a nice wrap-up for my PhD work but also features lots of great work from within the field of body-brain interaction that was a blast to read ❤️

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