Interesting how some amyloid cases show respect for the GBM, do not cross and do not cause significant podocyte injury or proteinuria. Probable LECT2 case, though pt has MGUS, so mass spec pending. #nephsky #pathsky #renalpath
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Immunofluorescence sensitivity for Ig-derived amyloidosis 84.6%. Remaining cases show weak staining for all antigens or lack of preferential staining for one antigen (https://pubmed.ncbi.nlm.nih.gov/31447055/) . Mass spec is needed even if LECT2 IHC positive to r/o concurrent AL given clinical MGUS.
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