The latest preprint from the lab. @lucassiemons.bsky.social improved the HMBC-HMQC method he had developed during his PhD with Flemming Hansen. The overall sensitivity gain in a 42 kDa kinase from BEST is 16% and 30% compared to the original scheme.
Reposted from
Magnetic Resonance News
Preprint, The BEST-HMBC-HMQC expt for pairing geminal methyl groups in Valine and Leucine side-chains. Ana P.A. Alva, Lucas Siemons, Ulric le Paige, Coline Wiame, Florence Cordier, Nicolas Wolff, Guillaume Bouvignies, Philippe Pelupessy, Fabien Ferrage chemrxiv.org/engage/chemr... #NMRchat #NMR 🧲
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Also check out the updated version of the program peakfit by the excellent @gbouvignies.bsky.social.
And thanks to Infranalytics @cnrs.bsky.social and the HIRES-MULTIDYN project @ec.europa.eu for funding.