New research reveals how tumors use the protein VDAC2 as a 'signal jammer' to evade immune responses. Removing VDAC2 could increase tumor cell death and make tumors more inflammatory, which enhances their sensitivity to immunotherapy.
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“We discovered a very potent way to enable cancers to be more responsive to T cells and immunotherapy by targeting proteins with dual protective roles in the tumor,” said Hongbo Chi, PhD.
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