Respiratory viruses like influenza and SARS-CoV-2 mainly infect the respiratory tract. Yet, with weakened immunity, they can disseminate. Influenza can be found in the intestinal tract and stool. www.sciencedirect.com/science/arti... - ThreadSky

marcveld.bsky.social • 92 days ago

Respiratory viruses like influenza and SARS-CoV-2 mainly infect the respiratory tract. Yet, with weakened immunity, they can disseminate. Influenza can be found in the intestinal tract and stool.
https://www.sciencedirect.com/science/article/pii/S1198743X16302154

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marcveld.bsky.social•92 days ago

Does it matter? For some viruses, persistence can become pathological. EBV is associated in some people with MS, HCV causes liver disease, HPV can induce cancer, etc. Typically, the immune system keeps viruses in check, clearing them from the body
https://www.nature.com/articles/nri1105

marcveld.bsky.social•92 days ago

As always, there are exceptions. Measles virus can cause severe disease a decade after initial infection when in exceptional cases it is not cleared and virions remain in the brain.
https://journals.asm.org/doi/abs/10.1128/jvi.59.2.472-478.1986

marcveld.bsky.social•92 days ago

Can SARS-CoV-2 hide? Like all viruses, it can disseminate and hide. This is not the norm. Is that of concern? Also here, most will be cleared, yet, there will be a fraction where this may not happen quickly, just like influenza and other HCoVs.
https://mmrjournal.biomedcentral.com/articles/10.1186/s40779-020-00279-z

marcveld.bsky.social•92 days ago

OC43 is of interest here, causing gastrointestinal issues in many infected. https://nature.com/articles/mi200879 There are no clear indications of pathological issues. We cannot be sure about SARS-CoV-2, which can disseminate to the intestine.

marcveld.bsky.social•92 days ago

Does this cause #LongCOVID? There are reports of finding viral ruminants. Logically, there is a correlation with disease severity. The more dissemination, the more you may detect it in quantity and at different sites. But, this is similar for LC patients and those who recovered.

marcveld.bsky.social•92 days ago

There has not been a clear indicator that the amount of remnants, their place, or their presence, is causative of #LongCovid. It has been a hypothesis, but this has not been substantiated with data.
https://x.com/Marc_Veld/status/1764402009279455525

julianoack.bsky.social•92 days ago

I thought Sars-CoV-2 infects all sorts of organs and tissue in the body - not just the respiratory tract. Wasn't that one of the most important findings, after, in the very beginnings of the pandemic, everyone used to focus mainly on the lungs?

marcveld.bsky.social•92 days ago

That is the same for most viruses and bacteria. It only happens if you cannot control the pathogen at the site of infection. This is why trained immune responses (immune memory) are so important to reduce risk of disease.

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