#Pericyte #PulmonaryHypertension
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A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
https://www.embopress.org/doi/full/10.1038/s44318-024-00349-1
1/2
A subpopulation of Higd1b+ lung capillary pericytes
👉Migrate to distal arteriole
👉Upregulate Vimentin
👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping)
in🐭Hypoxic PH
#SciArt
Ke Yuan lab @embojournal.org 2025
https://www.embopress.org/doi/full/10.1038/s44318-024-00349-1
Comments
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Mining #HumanLungCellAtlas #TabulaMurisSenis #Xenium 👤🫁 #SpatialTranscriptomics➡️
HIGD1B+ as a Lung-specific Pericyte marker (even more specific than NG2 or PDGFRβ😎)
Is there a direct functional role of HIGD1B in pericyte motility & morphogenesis?😆