SM22α+ #SmoothMuscleCell ATF3 KO🐭➡️ #AorticAneurysm #AorticRupture by AngII or #Aging

ATF3 physically sequestrates MDM2 (E3 ligase for p21)

ATF3 deficiency➡️
⏬p21 protein stability
⏫ds DNA breaks
⏫Micronuclei
⏫cGAS-STING
in SMCs

#AortaEd
Clin Transl Med 2024
https://onlinelibrary.wiley.com/doi/10.1002/ctm2.70147