It’s a big day for @genesandhealth.bsky.social @samcbhodgson.bsky.social @moneeza-ks.bsky.social Genes & Health, with @ Sam Hodgson, Moneeza Kalhan Siddiqui and I, as we publish our paper https://rdcu.be/d1vj0 on the genetic basis of #type2diabetes & #gestationaldiabetes (#T2D and #GDM) in south Asians. A🧵
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Focus is often put on lifestyle factors. We find that south Asians have a greater genetic risk of T2D than white Europeans. So, lifestyle is important, but south Asians carry a greater predisposition from genetic factors that they cannot change.
Partitioned polygenic scores helped us shine a light on the specific reasons for this:
Good question! This isn’t just about satisfying our curiosity. Partitioned polygenic scores point towards ways to improve T2D treatment. People with a high genetic risk for low insulin production were less likely to respond to SGLT2 inhibitors and more likely to need insulin treatment.