After a lot of work, we are finally able to share this project about the cell cycle in Marchantia from the Haseloff lab. If you want to find out how cell division is controlled, you can’t miss out this one… #PlantScience #Synbio #EvoDevo www.biorxiv.org/content/10.1... - ThreadSky

fromani.bsky.social • 84 days ago

After a lot of work, we are finally able to share this project about the cell cycle in Marchantia from the Haseloff lab. If you want to find out how cell division is controlled, you can’t miss out this one… #PlantScience #Synbio #EvoDevo

https://www.biorxiv.org/content/10.1101/2025.03.12.642684v1

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minyaaa.bsky.social•84 days ago

Amazing!!! Can’t wait to read it!!

kgeisler.bsky.social•80 days ago

Some great Marchantia work from the lab next door.

abdellahlakehal.bsky.social•84 days ago

Congrats!

fromani.bsky.social•84 days ago

In Eukaryotes, to coordinate replication with cell division, an elegant relay of cyclins and CDKs controls the transition between gap 1 (G1), replication (S), gap 2 (G2), to end in mitosis and start over again. You may have seen this plot in the Alberts manual, but is it true in any organism?

fromani.bsky.social•84 days ago

For example, in Arabidopsis you have 30 cyclins all over the place… Marchantia has a small set of cyclins, including 2 CYCD, 2 CYCB, and 1 CYCA. Phylogenetic analysis suggest that these genes are single copy in most related non-seed plant species too. (Why so many cyclins in flowering plants?)

fromani.bsky.social•84 days ago

During cell-cycle re-entry, only one of each cyclins is activated at a time. Looking at single cell data during progression, we manage to separate subclusters of three clear phases corresponding to G1, S, and G2/M. We find out that each cluster is governed by CYCD1/CDKA, CYCA/CDKA, and CYCB1/CDKB.

fromani.bsky.social•84 days ago

Is this true in vivo? We did translational reporters and validated this observation in vivo. Interestingly, CYCB is accumulated in the cytosol, but for a few minutes, it is translocated to the nuclei to start mitosis.

fromani.bsky.social•84 days ago

Using overexpression, we characterized how these cyclins affect cell division. We found that MpCYCD;1 is the rate limiting cyclin; MpCYCD;2 is not functional; and surprisingly, MpCYCB;1 and MpCYCA arrest cell division. This means that they need to be degraded to complete the process.

fromani.bsky.social•84 days ago

Marchantia has probably the most simple cell cycle control system ever described in plants and beyond. This has several evolutionary implications, it could help to unravel the system in flowering plants and find out how this system may work in ancestral eukaryotes.

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