Third, the context of assessing whether YOU should try hard to be your best self, or whether “I shouldn’t bother because my fate is determined by my genes”. (Spoiler: it’s the former!) (4/7)
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Fourth, the context of PGS & the Missing Heritability Problem. I’m a big advocate for “epistasis”, i.e. a nonlinear map from genome to (some but not all) outcomes. I argue that epistasis in human outcomes is widely misunderstood even by experts. (5/7)
Fifth, the context of trying to understand some outcome (schizophrenia, extroversion, or whatever) by studying the genes that correlate with it. I argue that this activity is useful on the margin and can be done well, despite the humiliating “candidate gene” fiasco of a couple decades ago. (6/7)
Again, here’s the link to the post! I’m learning as I go, happy for feedback & discussion! Thanks @ent3c.bsky.social for your book, which was exceptionally clear and helpful, even if I wound up disagreeing with parts of it. (7/7) https://www.lesswrong.com/posts/xXtDCeYLBR88QWebJ/heritability-five-battles
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