Hi BlueSky fam, for my first post and to celebrate our recent paper being physically published I thought I’d do a summary thread! This has been my most favourite (and toughest) work to date. Please help share around!! www.cell.com/cell/abstrac... (Reach out if you can’t access) - ThreadSky

bmunn.bsky.social • 72 days ago

Hi BlueSky fam, for my first post and to celebrate our recent paper being physically published I thought I’d do a summary thread!

This has been my most favourite (and toughest) work to date.

Please help share around!!

https://www.cell.com/cell/abstract/S0092-8674(24)01152-8
(Reach out if you can’t access)

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petep77.bsky.social•63 days ago

Thanks for posting. I read the abstract.

Could you please explain the paper in a way that a reasonably intelligent 6th grader could understand? Thanks.

bmunn.bsky.social•59 days ago

I can try! The brain is made of MANY cells creating everything that is us. When we look at a cell it seems to work very smart but independent yet when we look at all the cells they seem to work together + very safely. It seems cells interconnect in a complex ordered way that achieves both benefits!

bmunn.bsky.social•72 days ago

This combines all the science I love physics, info theory, modelling, and multiple species to understand what makes the brain so special!

It’s been cooking for the past four years, and only possible with the dream team

@macshine.bsky.social
@drbreaky.bsky.social and co!

bmunn.bsky.social•72 days ago

When I began working with Mac, we had “strong discussions” about how the brain coordinates activity to process information. Our different perspectives and starting points of macroscale vs. microscale, led to assumptions and predictions that didn’t always align.

bmunn.bsky.social•72 days ago

Inspired by multiscale analyses, I wanted to understand how both a macroscale/systems framework arguing for a resilient “population code” and a cellular/microscale perspective favouring a minimal redundant/efficient neuronal code can both simultaneously be consistent in neural data.

bmunn.bsky.social•72 days ago

Mac, being the fantastic boss he is, let me pursue an initially very 'physicsy' project and listened to my unhinged arguments about how straight lines on logarithmic axes, particularly their subtle changes can have significant functional implications for this question.

bmunn.bsky.social•72 days ago

We opted for a Kadanoff iterative coarse-graining approach among the growing multiscale techniques. This was dyadic (maximal log spread), comparable to standard analyses (correlations), and fast. Letting me track activity across scales

Crazily, I applied this to as many species as possible!

bmunn.bsky.social•72 days ago

We discovered a divergence in redundant information capacity at coarser scales.

This shows that the cellular scale is optimised for efficiency, while coarser ensembles support resiliency. This mirrored a shift from heavy-tailed to Gaussian correlation distributions.

nopainkiller.bsky.social•71 days ago

need access :(

bmunn.bsky.social•71 days ago

Thank you for the interest!

https://shine-lab.org/wp-content/uploads/2024/10/2024_cell.pdf

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