Null findings are important ‼️ Excited to share my latest work finding model-based planning does NOT improve following ketamine 💉, antidepressant 💊, or iCBT 👩‍💻 treatments 🧵👇🏻 - ThreadSky

kellydonegan.bsky.social • 126 days ago

Null findings are important ‼️ Excited to share my latest work finding model-based planning does NOT improve following ketamine 💉, antidepressant 💊, or iCBT 👩‍💻 treatments

🧵👇🏻

Reposted from PsyArXivBot

Model-based planning is unaffected by ketamine, antidepressant and internet delivered cognitive behavioural therapy treatments: http://osf.io/hbt6j/

Comments

chchatham.bsky.social•88 days ago

Really nice work. Do we know in these studies whether the participants *perceived* an improvement in cognition (regardless of whether two step could capture it)? My intuitive sense is that much of this may be a metacognitive phenomenon.

dpmoriarity.bsky.social•126 days ago

Excited to read! Appreciate you pursuing publishing a null- best of luck with publication

kellydonegan.bsky.social•126 days ago

Patients with depression often report cognitive problems incl. inhibition, task-shifting and updating; critical for model-based planning 💭 But, links with depression are unclear (small N’s & cross-sectional findings) & we don’t know IF or HOW treatments affect this capacity❓

kellydonegan.bsky.social•126 days ago

We leveraged two large within-person treatment seeking samples (incl. one of the biggest RCT’s in ketamine) and measured model-based planning & clinical states before/after a range of treatments 💉💊👩‍💻

🚨 Spoiler Alert: All treatments worked (mood ⬆️) but model-based planning remained unchanged

kellydonegan.bsky.social•126 days ago

In a iCBT arm (N=611), we replicated associations between model-based planning and compulsivity 🎉 but not depression

But we found the same story: while compulsivity ⬇️ following treatment, this was not accompanied by changes in model-based planning 🤔

kellydonegan.bsky.social•126 days ago

Take-aways: Model-based planning …
🍽️ does not improve following ketamine 💉, antidepressant 💊, or iCBT 👩‍💻
🍽️ is not necessarily compromised in depression & appears specifically linked to compulsivity
🍽️ may be trait-like rather than state-dependent

kellydonegan.bsky.social•126 days ago

Co-led by Shabnam Hossein, Rebecca Price, @clairegillan.bsky.social & co! 🌟

Happy reading! 📖

🔗 https://osf.io/preprints/psyarxiv/hbt6j

wordweaver.bsky.social•88 days ago

I am curious, would you say there's reason to believe that the arrow of causality runs the other way? Or does depression not correlate with model based planning at all

Comments

Posting Rules

Reply