Fascinating thread here: apparently, caffeine and ibuprofen both have binding affinity to their target proteins so weak that they might get tossed out of a typical drug discovery project!
Reposted from Kresten Lindorff-Larsen
What are some examples of weak-binding (approved) drugs?

I think memantine binds NMDAR with an affinity of about 1µM. Are there other such examples?

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