📢🧬Proud to announce our 1st work on pangenome graphs is early online @genomeresearch.bsky.social ! Here we developed an interpretative visualization framework for pangenome graphs named VRPG, which seamlessly bridges the graph and linear genomics world. genome.cshlp.org/content/earl... - ThreadSky

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evomicslab.bsky.social • 80 days ago

📢🧬Proud to announce our 1st work on pangenome graphs is early online @genomeresearch.bsky.social ! Here we developed an interpretative visualization framework for pangenome graphs named VRPG, which seamlessly bridges the graph and linear genomics world.
https://genome.cshlp.org/content/early/2025/01/13/gr.279461.124.abstract

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evomicslab.bsky.social•80 days ago

In the era of #T2T genomics, #pangenome graphs have emerged as a new paradigm for identifying, encoding, and presenting genomic variation at population levels. However, it remains challenging to dissect and interpret pangenome graphs in a biologically informative manner.

evomicslab.bsky.social•80 days ago

To facilitate better exploration & understanding of pangenome graphs towards novel biological insights, here we present a web-based interactive Visualization and interpretation framework for linear-Reference-projected Pangenome Graphs (VRPG).

evomicslab.bsky.social•80 days ago

VRPG provides efficient & intuitive supports for exploring and annotating pangenome graphs along a linear-genome-based coordinate system and offers many highly useful features such as in-graph path highlighting, CNV and SV characterization, graph-based sequence query, etc.

evomicslab.bsky.social•80 days ago

Especially, VRPG enables side-by-side visualization between the graph-based pangenome representation and the conventional primary-linear-reference-genome-based feature annotations, which greatly increases the Interpretability of pangenome graphs.

evomicslab.bsky.social•80 days ago

To further demonstrate its functionality & scalability, we applied VRPG to the cutting-edge yeast and human reference pangenome graphs via a dedicated web portal at https://evomicslab.org/app/vrpg/

evomicslab.bsky.social•80 days ago

Many thanks to our talented student Zepu Miao for leading the development of VRPG. Built upon VRPG, we are currently working on new development and discoveries with #pangenome graphs. Stay tuned!

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