There's a new class of pain med that interacts with the Nociceptin receptor, that may give opioid-level relief without their side effects or addictiveness. I first read about it a while ago. Hope they'll get one to market soon. Here's one that's in phase I trials: https://www.grunenthal.com/en/press-room/press-releases/2024/global-clinical-phase-i-programme-for-nop