Also transforming mast cell reactivity in those with MCAS. Not yet clear if it’s direct effect on mast cells or indirect from its effect on glucose regulation. - ThreadSky

ruhoy.bsky.social • 7 days ago

Also transforming mast cell reactivity in those with MCAS. Not yet clear if it’s direct effect on mast cells or indirect from its effect on glucose regulation.

Reposted from Michal Caspi Tal, PhD

GLP-1 drugs have transformed obesity and diabetes treatments, exhibiting profound weight loss and anti-inflammatory impact. Should we think about this like the good parts of a hookworm infection but with less of the bad parts of a hookworm infection?

pmc.ncbi.nlm.nih.gov/articles/PMC...

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wondermutt.bsky.social•7 days ago

Do you have links to any studies specifically linking semaglutide injections and MCAS?

bexstar.bsky.social•7 days ago

Interesting! Do you know if there are any trials on this or is it anecdotal reports?

richellesepulveda.bsky.social•7 days ago

It could be due to stabilizing ICP:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10151178/

floatinginthevoid.bsky.social•7 days ago

📌

chromatowski.bsky.social•7 days ago

richellesepulveda.bsky.social•7 days ago

There's been so much focus on the blood glucose effects, but there's quite a bit more that it does.

Plus, the weird glucose issues many ME/CFS people have suggest there is something else going on. My hypothesis is that the glucose spikes are trying to provide extra glucose to heal the brain.

chromatowski.bsky.social•7 days ago

So interesting. That lines up with my hypothesis about why adrenaline raises my level of functioning so drastically (the white coat effect for me is off the charts in this regard)—I strongly suspect it’s to do with getting glucose to my brain.

honeycrisp.bsky.social•7 days ago

That's fascinating. The one LC remission event I've had occurred after removing a decent-sized water snake from the playground at the school where I work. I figured adrenaline had mitigated symptoms bc of being an agonist. I hadn't thought about glucose involvement. Thanks for the tip!

richellesepulveda.bsky.social•7 days ago

I have something I am working on about the glucose and postprandial issues, and will be posting about it soon!

richellesepulveda.bsky.social•7 days ago

But since the cause of the inflammation is not so easily solved, the system gets "stuck" and instead of a temporary healing response, it causes downstream problems.

A symptom of this is postprandial tachycardia/malaise along with a glucose spike, regardless of the carb count of the meal.

richellesepulveda.bsky.social•7 days ago

Then reactive hypoglycemia kicks in after up to 3 hours.

I have had some success taking EXTRA glucose when this happens, and the blood glucose stabilizes without the big drop.

(The glucose spikes can happen even with just a fat challenge, no carbs at all!)

richellesepulveda.bsky.social•7 days ago

GLP-1 is also important in stabilizing CSF production, and can help with IIH. It is possible that MCAS stabilizes after the neuro inflammation from excessive ICP decreased.

Given the brain also produces GLP-1 in the cNTS, it would make sense that there are connections to cervical instability.

karmallama.bsky.social•7 days ago

It has not helped my long covid induced MCAS at all. But it has been great for my pancreas.

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