Remarkably, we found seven embryos that did not have a single crossover!
These embryos had both maternal chrs genome-wide.
(Except chrs with an additional aneuploidy; see figure for SNP array validation of one such embryo.)
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These embryos had both maternal chrs genome-wide.
(Except chrs with an additional aneuploidy; see figure for SNP array validation of one such embryo.)
6/9
Comments
Naturally, these embryos have high levels of homozygosity.
How the paternal genome disappeared is unknown.
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Finally, ploidy aberrations tends to cluster in families: six couples had three affected embryos (four with female age<35), unexpected by chance, suggesting a genetic basis.
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Identifying and understanding these errors will contribute to explaining meiosis and infertility.
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