1/n 🚨 New Review Alert! 🚨 Excited to share our open-access review, Choroid Plexus Pathophysiology, published in Annual Review of Pathology! The ChP is a small but mighty structure at the heart of CNS health, disease, and therapeutic potential. #science 🧪 www.annualreviews.org/content/jour... - ThreadSky

scienceyael.bsky.social • 31 days ago

1/n 🚨 New Review Alert! 🚨

Excited to share our open-access review, Choroid Plexus Pathophysiology, published in Annual Review of Pathology! The ChP is a small but mighty structure at the heart of CNS health, disease, and therapeutic potential. #science 🧪

https://www.annualreviews.org/content/journals/10.1146/annurev-pathmechdis-051222-114051

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scienceyael.bsky.social•31 days ago

1/ The choroid plexus (ChP) isn’t just a CSF producer. It’s a dynamic interface between the brain and body, playing key roles in immune regulation, maintaining the blood-CSF barrier, and secreting signaling molecules critical for CNS health.

scienceyael.bsky.social•31 days ago

2/ The ChP also controls fluid dynamics in the brain. Dysfunction—like overproduction of CSF or barrier breakdown—can contribute to conditions like #hydrocephalus. Targeting its secretory function could reduce invasive treatments.

scienceyael.bsky.social•31 days ago

3/ #Pathogens frequently exploit the ChP to breach the CNS. Toxoplasma gondii, Neisseria meningitidis, and others hijack the ChP barrier, causing infections like encephalitis or #meningitis. Understanding this gateway could help prevent CNS infections.

scienceyael.bsky.social•31 days ago

4/ Another key role of the ChP is regulating trace metals like iron, zinc, and copper in the brain. Disruptions in metal transport are linked to #neurodegenerative diseases like Wilson’s and Parkinson’s and some developmental disorders.

scienceyael.bsky.social•31 days ago

5/ Despite its challenges, the ChP is a therapeutic goldmine. Its fenestrated capillaries make it a promising site for delivering drugs to the CNS, bypassing the blood-brain barrier. Modulating its secretions could also restore healthy CSF composition.

scienceyael.bsky.social•31 days ago

6/ #Aging has profound effects on the ChP. Its barrier weakens, making the brain more vulnerable to toxins. At the same time, it secretes fewer protective factors, driving neuroinflammation and cognitive decline.

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