Excited to share my first postdoc paper - a tool to engineer mtDNA deletions in human cells and study their pathogenic impact ✂️🧬🧫
Reposted from
Agnel Sfeir
Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...
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