Published estimates suggesting a survival advantage from giving polyclonal intravenous immunoglobulin in streptococcal toxic shock syndrome are explained, at least in part, by immortal time bias
Reposted from Tom Yates
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Enjoyed working with @tom-parks.bsky.social and @petedodd24.bsky.social on immortal time bias

In its simplest form, ITB results from misallocation of person time, i.e. pre treatment time in intervention group being counted as time on treatment

www.medrxiv.org/content/10.1...

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