Building the body of an embryo or maintaining tissues in adults rely on cell migration. From neural crest cells leaving the neural tube to form our peripheral nervous system to migrating lateral line cells in a zebrafish to skin cells migrating to repair wounds, its key 1/n youtu.be/IqUs29Kz3HE?... - ThreadSky

peiferlabunc.bsky.social • 81 days ago

Building the body of an embryo or maintaining tissues in adults rely on cell migration. From neural crest cells leaving the neural tube to form our peripheral nervous system to migrating lateral line cells in a zebrafish to skin cells migrating to repair wounds, its key 1/n
https://youtu.be/IqUs29Kz3HE?si=c82hH6z2zdobk_Wj

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peiferlabunc.bsky.social•81 days ago

Regulation of this process is key, as deregulated migration drives tumor cells metastasis, as they leave the primary tumor and migrate to distant sites. 2/n
https://youtu.be/buEyalnXk-w?si=q_xzZXEuRa4zlpHS

peiferlabunc.bsky.social•81 days ago

We often think of tissue cells as either epithelial, maintaining strong cell adhesion & forming sheets, like our skin or the lining of our gut, or as mesenchymal, only loosely attached and more individual, like migrating neural crest cells or even individual lymphocytes. 3/n

peiferlabunc.bsky.social•81 days ago

However, we now appreciate that the distinction between epithelial and mesenchymal cells is not a YES/NO difference but a spectrum. Cells can vary in their properties across this spectrum. 4/n

peiferlabunc.bsky.social•81 days ago

Postdoc @maikbischoff.bsky.social wants to define the molecular machines driving cell migration in vivo. As a PhD student he developed an exciting new system to study this. 5/n

peiferlabunc.bsky.social•81 days ago

The adult fruit fly testis is a long, spiral shaped tube encased in bands of circumferential muscle. During pupal development muscle precursors migrate onto the testis 6/n

peiferlabunc.bsky.social•81 days ago

One can observe the myoblasts migrating at high resolution and manipulate their genomes using the powerful tools available in Drosophila. This offered Maik a chance to define the mechanisms driving migration. 7/n

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