Yitong discovered that both the speed of chromosome movements and spindle size scale with the space available to nuclei in the blastoderm embryo. The scaling of chromosome speed correlated with the poleward flux of microtubules, arguing that it might be controlled by the rate of MT depolymerization. - ThreadSky

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ditalialab.bsky.social • 80 days ago

Yitong discovered that both the speed of chromosome movements and spindle size scale with the space available to nuclei in the blastoderm embryo. The scaling of chromosome speed correlated with the poleward flux of microtubules, arguing that it might be controlled by the rate of MT depolymerization.

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ditalialab.bsky.social•80 days ago

Consistently with this, we found that several motors involved in MT depolymerization could all impact chromosome speed when their amounts were genetically reduced. This pointed to a possible global regulator of MT dynamics and we turned our attention to the cell cycle.

ditalialab.bsky.social•80 days ago

Yitong discovered that there is a tight correlation between the speed of chromosome separation and the duration of anaphase and that in turn this duration is mainly set by the activity of mitotic kinases Cdk1 and Polo and the mitotic phosphatase PP2A-B55.

ditalialab.bsky.social•80 days ago

While the cell cycle is the dominant mechanism controlling chromosome speed, careful data analysis suggests residual contributions from spindle length through mechanisms that remain to be elucidated at this point.

ditalialab.bsky.social•80 days ago

Most notably, we found a quantitative relationship (previously unknown to the best of our knowledge) between the speed of chromosome movement and the rate at which nuclei complete anaphase (likely set by the rate of dephosphorylation of mitotic targets). Excited to see if this is conserved.

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