In our new paper @dulaclab.bsky.social, we investigated a fundamental question in social neuroscience: the origin of "sociality" (the need of being together) at the levels of behavior, neuron type, neural circuit and sensory modulation. (Detailed digest below) (1/7) www.nature.com/articles/s41... - ThreadSky

dingliu.bsky.social • 1 day ago

In our new paper @dulaclab.bsky.social, we investigated a fundamental question in social neuroscience: the origin of "sociality" (the need of being together) at the levels of behavior, neuron type, neural circuit and sensory modulation. (Detailed digest below) (1/7)
https://www.nature.com/articles/s41586-025-08617-8

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tusharora9.bsky.social•1 day ago

beautiful work !!! congratulations...

dingliu.bsky.social•1 day ago

First, we characterized a "social rebound" behavior triggered by social isolation, which suggests a homeostatic regulation of social need. Intriguingly, different mouse strains showed distinct social rebound intensity after isolation, indicating a genetic basis for social need. (2/7)

dingliu.bsky.social•1 day ago

We further identified two molecularly defined interconnected neuronal populations in the hypothalamus, one activated by social isolation, the other by social reunion, together mediating a dynamic balance between “social need” and “social satiety” states. (3/7)

dingliu.bsky.social•1 day ago

Via projections to oxytocin neurons, lateral habenula and arcuate nucleus, Isolation neurons coordinate the enhanced social drive, aversive emotion and inhibition of eating during short-term social isolation. The projections from Reunion neurons to VTA led to dopamine release during reunion. (4/7)

dingliu.bsky.social•1 day ago

We also found that touch is a key sensory modality for mice to perceive social environment, with lack of touch sensation leading to the emergence of social need, and its presence providing social satiety. (5/7)

dingliu.bsky.social•1 day ago

Thank all the collaborators and lab members for their contribution and superb teamwork: @naoshigeuchida.bsky.social @Mitsuko Watabe-Uchida, @Ryunosuke Amo @Iku Tsutsui-Kimura @David Ginty @ssebastianchoi.bsky.social @ishmailsaboor.bsky.social (6/7)

dingliu.bsky.social•1 day ago

And the colleagues from the Dulac lab: @mostafizurrahman.bsky.social @Autumn Johnson @Zuri A. Sullivan @Nicolai Pena @Mustafa Talay @blogeman.bsky.social @Samantha Finkbeiner @Lechen Qian @Athena Capo-Battaglia (7/7)

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