I'll post more about this later. But for a long time, we've observed odd behavior of AlphaFold's ipTM in the presence of disorder and accessory domains. Looking into the math points a way to solving the problem. There are other solutions besides ours. But I think understanding the math is key.
Reposted from bioRxiv Bioinfo
Res ipSAE loquunt: What's wrong with AlphaFold's ipTM score and how to fix it https://www.biorxiv.org/content/10.1101/2025.02.10.637595v1

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