Context is everything! (N-) #degron specificity of a #ubiquitin ligase reprogrammed under #proteotoxic stress. Interesting implications for biology, drug design and how we assess E3 specificity....
Reposted from
The EMBO Journal
Yeast #proteotoxic stress response: Intrinsically disordered protein Roq1 reprograms specificity of #ubiquitin ligase Ubr1 towards four distinct classes of substrates using its N-terminal arginine linked to a short hydrophobic motif
Sebastian Schuck and colleagues
www.embopress.org/doi/full/10....
Sebastian Schuck and colleagues
www.embopress.org/doi/full/10....
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