While this is an interesting piece - there are quite a few issues that have slipped through peer review here: e.g. controlling for heteroplasmy levels in their patient associations (the mutation calls for which are not properly provided in source data) ED Fig 9 @natureportfolio.bsky.social
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Payam Gammage
It’s a big week for mtDNA @nature - tumours taking up mtDNA from the stroma is an increasingly established phenomenon (without much solid mechanism yet), but the backflow of mtDNA into immune cells is an intriguing observation. www.nature.com/articles/s41...
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https://www.science.org/doi/10.1126/science.abq1053
https://www.nature.com/articles/s43018-024-00895-x